Adelle Burns left a note telling her mom that she would be with friend's in Mississippi, but there has been no word from her since.
Her mom Glenna Phillips told the Tallahassee Democrat that the family "just want her home."
"We want her home and we hope she is sage wherever she's at," she said. "Somebody is helping her. A 14-year-old cannot run away and survive on her own without money or anything. There are so many ifs in this situation."
The family is offering a $1,000 reward for information leading to her return.
The Leon County Sheriff's Office said they did not consider Burns to be at risk, but spokesperson James McQuaig told the paper, "there's a great concern for this child's safety."